Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy

Our paper on modeling PSA (Prostate-Specific Antigen) and exploring differences in more accurate panels (so-called ultrasensitive-PSA, u-PSA) and the traditional higher concentration ranges ("traditional-PSA") is out:

http://www.nature.com/articles/srep36161

Overall, ultrasensitive-PSA seems robust and has potential for early prediction of biochemical relapse. I acknowledge that there are a lot of criticism pointed towards ultrasensitive-PSA, e.g. that even low levels of PSA can be detected in women, but with feasible mathematical modeling one can predict PSA curvature quite early after radical prostatectomy. Hopefully this will lead towards more interest in exploring clinical potential in u-PSA.

Early detection of relapse may make the difference between life and death.

-TDL